The Combination of Ultraviolet-B and Vitamin K2 Exposure Effect on Fibroblast-like cell Number in Wistar Rats

Background: Vitamin D deficiency in children is one of the problems most often discussed and received attention from around world today, especially during Corona virus disease-19 (Covid-19) pandemic. D3 increases production vitamin K2 protein activates a involved bone metabolism. formation by stimulating osteoblast differentiation, regulating mineralization extracellular matrix, marker gene expression, inhibiting osteoclastogenesis. Purpose: to analyzed effect sun exposure, Ultraviolet-B (UV-B) supplementation on fibroblast-like cell as Wistar rats (Rattus novergicus). Methods: twenty-four samples divided into 4 groups namely control group, UV-B combination group. After 21 days, extraction lower incisors was done examine number ​​after treatment. being decalcified, specimens underwent histological evaluation using Haemotoxylin Eosin staining observe number. Result: Data analysis fibroblast like cells expression way variance (ANOVA) test showed significant difference between sample (p<0.05). Conclusion: The exposure administration group increased (R.